Imaging the aging brain: study design and baseline findings of the SENIOR cohort.

ABSTRACT:

Background

Current demographic trends point towards an aging society entailing increasing occurrence and burden of neurodegenerative diseases. In this context, understanding physiological aging and its turning point into neurodegeneration is essential for the development of possible biomarkers and future therapeutics of brain disease.

Methods

The SENIOR study represents a longitudinal, observational study including cognitively healthy elderlies aged between 50 and 70 years old at the time of inclusion, being followed annually over 10 years. Our multimodal protocol includes structural, diffusion, functional, and sodium magnetic resonance imaging (MRI) at 3 T and 7 T, positron emission tomography (PET), blood samples, genetics, audiometry, and neuropsychological and neurologic

SUBMITTER: Haeger A 

PROVIDER: S-EPMC7320588 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature