How to get your goat: automated identification of species from MALDI-ToF spectra.

ABSTRACT:

Motivation

Classification of archaeological animal samples is commonly achieved via manual examination of matrix-assisted laser desorption/ionization time-of-flight (MALDI-ToF) spectra. This is a time-consuming process which requires significant training and which does not produce a measure of confidence in the classification. We present a new, automated method for arriving at a classification of a MALDI-ToF sample, provided the collagen sequences for each candidate species are available. The approach derives a set of peptide masses from the sequence data for comparison with the sample data, which is carried out by cross-correlation. A novel way of combining evidence from multiple marker peptides is used to interpret the raw alignments and arrive at a classification with an associa

SUBMITTER: Hickinbotham S 

PROVIDER: S-EPMC7320604 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature