CScape-somatic: distinguishing driver and passenger point mutations in the cancer genome.

ABSTRACT:

Motivation

Next-generation sequencing technologies have accelerated the discovery of single nucleotide variants in the human genome, stimulating the development of predictors for classifying which of these variants are likely functional in disease, and which neutral. Recently, we proposed CScape, a method for discriminating between cancer driver mutations and presumed benign variants. For the neutral class, this method relied on benign germline variants found in the 1000 Genomes Project database. Discrimination could, therefore, be influenced by the distinction of germline versus somatic, rather than neutral versus disease driver. This motivates this article in which we consider predictive discrimination between recurrent and rare somatic single point mutations based solely on usin

SUBMITTER: Rogers MF 

PROVIDER: S-EPMC7320610 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature