APAlyzer: a bioinformatics package for analysis of alternative polyadenylation isoforms.

ABSTRACT:

Summary

Most eukaryotic genes produce alternative polyadenylation (APA) isoforms. APA is dynamically regulated under different growth and differentiation conditions. Here, we present a bioinformatics package, named APAlyzer, for examining 3'UTR APA, intronic APA and gene expression changes using RNA-seq data and annotated polyadenylation sites in the PolyA_DB database. Using APAlyzer and data from the GTEx database, we present APA profiles across human tissues.

Availability and implementation

APAlyzer is freely available at https://bioconductor.org/packages/release/bioc/html/APAlyzer.html as an R/Bioconductor package.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Wang R 

PROVIDER: S-EPMC7320624 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature