Catalytic activity regulation through post-translational modification: the expanding universe of protein diversity.

ABSTRACT: Protein composition is restricted by the genetic code to a relatively small number of natural amino acids. Similarly, the known three-dimensional structures adopt a limited number of protein folds. However, proteins exert a large variety of functions and show a remarkable ability for regulation and immediate response to intracellular and extracellular stimuli. To some degree, the wide variability of protein function can be attributed to the post-translational modifications. Post-translational modifications have been observed in all kingdoms of life and give to proteins a significant degree of chemical and consequently functional and structural diversity. Their importance is partly reflected in the large number of genes dedicated to their regulation. So far, hundreds of post-translational m

SUBMITTER: Kokkinidis M 

PROVIDER: S-EPMC7320668 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature