The prognostic significance of BMI1 expression in invasive breast cancer is dependent on its molecular subtypes.

ABSTRACT:

Purpose

BMI1, which is a major component of the polycomb group complex 1, is an essential epigenetic repressor of multiple regulatory genes and has been identified as a cancer stem cell (CSC) marker in several cancers. However, its role in breast cancer (BC) remains to be defined. In this study, we have evaluated the prognostic significance of BMI1 among the different molecular subtypes and assessed its association with other breast CSC markers (BCSC).

Material and method

BMI1 copy number and mRNA was assessed in large and well-characterised cohorts of early-stage BC patients [METABRIC (n = 1980) and the Bc-GenExMiner (n = 9616) databases]. BMI1 protein expression was assessed using tissue microarray and immunohistochemistry in a cohort of 870 invasive BC patients with long-

SUBMITTER: Althobiti M 

PROVIDER: S-EPMC7320923 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature