Autonomic failure in Parkinson's disease is associated with striatal dopamine deficiencies.

ABSTRACT: Autonomic dysfunction is a common non-motor symptom in Parkinson's disease (PD). Dopamine and serotonin are known to play a role in autonomic regulation, and, therefore, PD-related degeneration of serotonergic and dopaminergic neurons in these regions may be associated with autonomic dysfunction. We sought to clarify the association between extrastriatal serotonergic and striatal dopaminergic degeneration and the severity of autonomic symptoms, including gastrointestinal, pupillomotor, thermoregulatory, cardiovascular, and urinary dysfunction. We performed hierarchical multiple regression analyses to determine the relationships between (extra)striatal serotonergic and dopaminergic degeneration and autonomic dysfunction in 310 patients with PD. We used [¹²³I]FP-CIT SPECT binding

SUBMITTER: van Deursen DN 

PROVIDER: S-EPMC7320937 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature