Pharmacokinetic Properties of ⁶⁸Ga-labelled Folic Acid Conjugates: Improvement Using HEHE Tag.

ABSTRACT: The folate receptor (FR) is a promising cell membrane-associated target for molecular imaging and radionuclide therapy of cancer (FR-α) and potentially also inflammatory diseases (FR-β) through use of folic acid-based radioconjugate. FR is often overexpressed by cells of epithelial tumors, including tumors of ovary, cervix, endometrium, lungs, kidneys, etc. In healthy tissues, FR can be found in small numbers by the epithelial cells, mainly in the kidneys. Extremely high undesired accumulation of the folate radioconjugates in the renal tissue is a main drawback of FR-targeting concept. In the course of this work, we aimed to reduce the undesirable accumulation of folate radioconjugates in the kidneys by introducing a histidine/glutamic acid tag into their structure. Two folic acid based co

SUBMITTER: Larenkov A 

PROVIDER: S-EPMC7321154 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature