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Five New Pregnane Glycosides from Gymnema sylvestre and Their ?-Glucosidase and ?-Amylase Inhibitory Activities.

ABSTRACT: Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A-E (1-5) and four known oleanane saponins, 3?-O-?-D-glucopyranosyl (1?6)-?-D-glucopyranosyl oleanolic acid 28-O-?-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3?-O-?-D-xylopyranosyl-(1?6)-?-D- glucopyranosyl-(1?6)-?-D-glucopyranosyl oleanolic acid 28-O-?-D-glucopyranosyl ester (8), and alternoside XIX (9). Their structures were identified based on spectroscopic evidence and comparison with those reported in the literature. All compounds were evaluated for their ?-glucosidase and ?-amylase inhibitory activities. Compounds 2-4 showed significant ?-amylase inhibitory activity, with IC50 values ranging from 113.0 to 176.2 µM.

SUBMITTER: Kiem PV

PROVIDER: S-EPMC7321224 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Five New Pregnane Glycosides from Gymnema sylvestre and Their α-Glucosidase and α-Amylase Inhibitory Activities.

Kiem Phan Van PV Yen Duong Thi Hai DTH Hung Nguyen Van NV Nhiem Nguyen Xuan NX Tai Bui Huu BH Trang Do Thi DT Yen Pham Hai PH Ngoc Tran Minh TM Minh Chau Van CV Park SeonJu S Lee Jae Hyuk JH Kim Sun Yeou SY Kim Seung Hyun SH

Molecules (Basel, Switzerland) 20200528 11

Gymnema sylvestre, a medicinal plant, has been used in Indian ayurvedic traditional medicine for the treatment of diabetes. Phytochemical investigation of Gymnema sylvestre led to the isolation of five new pregnane glycosides, gymsylosides A-E (1-5) and four known oleanane saponins, 3β-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl oleanolic acid 28-O-β-D-glucopyranosyl ester (6), gymnemoside-W1 (7), 3β-O-β-D-xylopyranosyl-(1→6)-β-D- ...[more]

PMID: 32481737

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Dataset Information

Five New Pregnane Glycosides from Gymnema sylvestre and Their ?-Glucosidase and ?-Amylase Inhibitory Activities.

Publications

Five New Pregnane Glycosides from <i>Gymnema sylvestre</i> and Their α-Glucosidase and α-Amylase Inhibitory Activities.

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