Dendrimer-Functionalized Hybrid Materials Based on Silica as Novel Carriers of Bioactive Acids.

ABSTRACT: One of the major goals in the materials science is the design and development of non-toxic, versatile, and efficient drug delivery systems. The study reported in this paper concerns the syntheses of poly(amidoamine) (PAMAM) dendrimers with tris(2-aminoethyl)amine as an amine core and different terminal amines, and their attachment to silica matrix. The obtained ethylenediamine (EDA), triethylenetetramine (TETA), tris(2-aminoethyl)amine (TREN) and 4,7,10-trioxa-1,13-tridecanediamine (TRI-OXA) dendrimers were introduced to the support surface via an epoxy linker, leading to a loading efficiency in the range of 0.054-0.113 mmol g-1, determined using elemental and thermogravimetric analyses. The materials exhibited high adsorption capacities towards the chosen model drugs: folic, salicylic and

SUBMITTER: Pawlaczyk M 

PROVIDER: S-EPMC7321234 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature