Encapsidation of Different Plasmonic Gold Nanoparticles by the CCMV CP.

ABSTRACT: Different types of gold nanoparticles have been synthesized that show great potential in medical applications such as medical imaging, bio-analytical sensing and photothermal cancer therapy. However, their stability, polydispersity and biocompatibility are major issues of concern. For example, the synthesis of gold nanorods, obtained through the elongated micelle process, produce them with a high positive surface charge that is cytotoxic, while gold nanoshells are unstable and break down in a few weeks due to the Ostwald ripening process. In this work, we report the self-assembly of the capsid protein (CP) of cowpea chlorotic mottle virus (CCMV) around spherical gold nanoparticles, gold nanorods and gold nanoshells to form virus-like particles (VLPs). All gold nanoparticles were synthesize

SUBMITTER: Duran-Meza AL 

PROVIDER: S-EPMC7321416 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature