Quinoline‑ and Benzoselenazole-Derived Unsymmetrical Squaraine Cyanine Dyes: Design, Synthesis, Photophysicochemical Features and Light-Triggerable Antiproliferative Effects against Breast Cancer Cell Lines.

ABSTRACT: Photodynamic therapy is an innovative treatment approach broadly directed towards oncological diseases. Its applicability and efficiency are closely related to the interaction of three main components, namely a photosensitizer, light and molecular triplet oxygen, which should drive cell death. Recently, several studies have demonstrated that squaraine cyanine dyes have a set of photophysical and photochemical properties that have made of these compounds' potential photosensitizers for this therapeutic modality. In the present research work, we describe the synthesis and characterization of four quinoline‑ and benzoselenazole‑derived unsymmetrical squaraine cyanine dyes. Except for the precursor of aminosquaraine dyes, i.e., O‑methylated derivative, all dyes were evaluated for their behavio

SUBMITTER: Lima E 

PROVIDER: S-EPMC7321604 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature