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Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression.

ABSTRACT: MYCN-amplified neuroblastoma (NB) cells exhibit transcriptional activation of human telomerase reverse transcriptase (hTERT) expression. hTERT promoter-driven oncolytic adenoviruses OBP-301 and OBP-702 exhibited a strong antitumor effect in human MYCN-amplified NB cells via induction of autophagy and E2F1-mediated MYCN suppression.

SUBMITTER: Tanimoto T

PROVIDER: S-EPMC7321810 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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PRC1.6 molecule L3MBTL2 protects MYCN-amplified neuroblastoma cells via epigenetic gene suppression

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