Risk of major bleeding associated with aspirin use in non-surgical critically ill patients receiving therapeutic anticoagulation.

ABSTRACT:

Background

We aimed to evaluate the risk of major bleeding in non-surgical critically ill patients who received aspirin in conjunction with therapeutic anticoagulation (concomitant therapy) compared to those who received therapeutic anticoagulation alone.

Methods

This is a retrospective cohort study of critically ill patients initiated on therapeutic anticoagulation at a large academic medical center from 2007 to 2016. The exposure of interest was aspirin therapy during anticoagulation. The primary outcome was the incidence of major bleeding during hospitalization. Secondary outcomes included in-hospital mortality, hospital free days, and new myocardial infarction or stroke.

Results

5507 (73.2%) patients received anticoagulation alone and 2014 (26.8%) received concomi

SUBMITTER: Subat YW 

PROVIDER: S-EPMC7321912 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature