A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.

ABSTRACT: Implantation is initiated when an embryo attaches to the uterine luminal epithelium and subsequently penetrates into the underlying stroma to firmly embed in the endometrium. These events are followed by the formation of an extensive vascular network in the stroma that supports embryonic growth and ensures successful implantation. Interestingly, in many mammalian species, these processes of early pregnancy occur in a hypoxic environment. However, the mechanisms underlying maternal adaptation to hypoxia during early pregnancy remain unclear. In this study, using a knockout mouse model, we show that the transcription factor hypoxia-inducible factor 2 alpha (Hif2α), which is induced in subluminal stromal cells at the time of implantation, plays a crucial role during early pregnancy. Indeed, w

SUBMITTER: Bhurke A 

PROVIDER: S-EPMC7321991 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature