A long noncoding RNA regulates inflammation resolution by mouse macrophages through fatty acid oxidation activation.

ABSTRACT: Proper resolution of inflammation is vital for repair and restoration of homeostasis after tissue damage, and its dysregulation underlies various noncommunicable diseases, such as cardiovascular and metabolic diseases. Macrophages play diverse roles throughout initial inflammation, its resolution, and tissue repair. Differential metabolic reprogramming is reportedly required for induction and support of the various macrophage activation states. Here we show that a long noncoding RNA (lncRNA), lncFAO, contributes to inflammation resolution and tissue repair in mice by promoting fatty acid oxidation (FAO) in macrophages. lncFAO is induced late after lipopolysaccharide (LPS) stimulation of cultured macrophages and in Ly6C^hi monocyte-derived macrophages in damaged tiss

SUBMITTER: Nakayama Y 

PROVIDER: S-EPMC7322040 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature