Dynamic association between AT(N) profile and cognition mediated by cortical thickness in Alzheimer's continuum.

ABSTRACT:

Background

The recently-proposed National Institute on Aging and Alzheimer's Association research framework organizes Alzheimer's disease (AD) biomarkers based on amyloid/tau/neurodegeneration (AT(N)). This study investigated the mediating effect of structural change in brain MRI on changes in cognitive function according to initial AT(N) profiles.

Methods

We included 576 subjects (cognitively unimpaired (N = 136), mild cognitive impairment (N = 294), dementia (N = 146)) from the Alzheimer's disease Neuroimaging Initiative study. The parallel-process latent growth curve model was applied to test the mediational effect of cortical thickness growth trajectory between the initial AT(N) profiles and cognitive growth trajectory.

Results

In Alzheimer's continuum, only the A

SUBMITTER: Jang JW 

PROVIDER: S-EPMC7322096 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature