STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue.

ABSTRACT:

Objective

Increasing energy expenditure through activation of brown adipose tissue (BAT) thermogenesis is an attractive approach to counteract obesity. It is therefore essential to understand the molecular mechanisms that control BAT functions. Until now several members of the Janus kinase (JAK) - signal transducer and activator of transcription (STAT) pathway have been implicated as being relevant for BAT physiology. However, whether the STAT family member STAT5 is important for the thermogenic property of adipose tissues is unknown. Therefore, we have investigated the role of STAT5 in thermogenic fat in this paper.

Methods

We performed metabolic and molecular analyses using mice that harbor an adipocyte-specific deletion of Stat5a/b alleles.

Results

We found that ST

SUBMITTER: Kaltenecker D 

PROVIDER: S-EPMC7322099 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature