Mathematical modeling of PDGF-driven glioma reveals the dynamics of immune cells infiltrating into tumors.

ABSTRACT:

Background

Tumor-infiltrated immune cells compose a significant component of many cancers. They have been observed to have contradictory impacts on tumors. Although the primary reasons for these observations remain elusive, it is important to understand how immune cells infiltrating into tumors is regulated. Recently our group conducted a series of experimental studies, which showed that muIDH1 gliomas have a significant global reduction of immune cells and suggested that the longer survival time of mice with CIMP gliomas may be due to the IDH mutation and its effect on reducing of the tumor-infiltrated immune cells. However, to comprehend how IDH1 mutants regulate infiltration of immune cells into gliomas and how they affect the aggressiveness of gliomas, it is necessary to integr

SUBMITTER: Niu B 

PROVIDER: S-EPMC7322103 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature