The association between adiponectin gene rs182052 polymorphism and cancer risk: a meta-analysis.

ABSTRACT:

Background

The evidence for an association between the adiponectin gene (ADIPOQ) polymorphism rs182052 and cancer risk is inconsistent. We performed a meta-analysis to obtain more precise conclusions.

Methods

The PubMed, Embase, and Web of Science databases were searched until July 11, 2019. And seven epidemiology studies were retrieved, including 4,929 cases and 5,625 controls. Odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were calculated to evaluate the strength of the association.

Results

The meta-analysis demonstrated that rs182052 significantly increased the risk of cancer under the allele, homozygote, dominant, and recessive models, based on an overall analysis (A vs. G: OR, 1.09, 95% CI, 1.03-1.15, P=0.003; AA vs. GG: OR, 1.20, 95% CI,

SUBMITTER: Wu LF 

PROVIDER: S-EPMC7322108 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature