Dynamics of vitamin A uptake, storage, and utilization in vocal fold mucosa.

ABSTRACT:

Objective

Extrahepatic vitamin A is housed within organ-specific stellate cells that support local tissue function. These cells have been reported in the vocal fold mucosa (VFM) of the larynx; however, it is unknown how vitamin A reaches and is disseminated among VFM target cells, how VFM storage and utilization vary as a function of total body stores, and how these parameters change in the context of pathology. Therefore, in this study, we investigated fundamental VFM vitamin A uptake and metabolism.

Methods

Using cadaveric tissue and serum from human donors representing the full continuum of clinical vitamin A status, we established a concentration range and analyzed the impact of biologic and clinical covariates on VFM vitamin A. We additionally conducted immunodetection

SUBMITTER: Nishimoto K 

PROVIDER: S-EPMC7322172 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature