NRF2 pathway activation by KEAP1 inhibition attenuates the manifestation of aging phenotypes in salivary glands.

ABSTRACT: Saliva plays an essential role in the maintenance of oral health. The oral cavity environment changes during aging mainly due to alterations in the secretion and composition of saliva. In particular, unstimulated basal salivary flow decreases with age. The functional decline of the salivary glands impairs chewing and swallowing abilities and often becomes one of the predispositions for aging-related disorders, including aspiration pneumonia. The KEAP1-NRF2 system plays a central role in the regulation of the oxidative stress response. NRF2 is a transcription factor that coordinately regulates cytoprotective genes, and KEAP1 is a negative regulator of NRF2. Although NRF2 activation has been suggested to be advantageous for the prevention of aging-related diseases, its role in the course of

SUBMITTER: Wati SM 

PROVIDER: S-EPMC7322188 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature