Immune-infiltration based signature as a novel prognostic biomarker in gastrointestinal stromal tumour.

ABSTRACT:

Background

Accumulating evidence indicates that tumour-infiltrating lymphocytes (TILs) are the primary determinant of survival outcomes in various tumours. Thus, we sought to investigate the TIL distribution and density in gastrointestinal stromal tumours (GISTs) and to develop an immune infiltration (II)-based signature to predict prognosis.

Methods

The expression of 8 immune features in the tumour centre (TC) and tumour margin (TM) and PD-L1 in 435 GIST patients was investigated by immunohistochemistry. Then, a 4-feature-based II-GIST signature integrating the CD3⁺ TC, CD3⁺ TM, CD8⁺ TM and CD45RO⁺ TM parameters was developed using a LASSO Cox regression model in the training cohort and was validated in two separate validation coh

SUBMITTER: Wei ZW 

PROVIDER: S-EPMC7322257 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature