Characterizing the heterogeneous metabolic progression in idiopathic REM sleep behavior disorder.

ABSTRACT:

Objective

Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD) is a prodromal stage of synucleinopathies such as Parkinson's disease (PD). Positron emission tomography (PET) with ¹⁸F-FDG reveals metabolic perturbations, which are scored by spatial covariance analysis. However, the resultant pattern scores do not capture the spatially heterogeneous trajectories of metabolic changes between individual brain regions. Assuming metabolic progression occurs as a continuum from the healthy control (HC) condition to iRBD and then PD, we investigated spatial dynamics of progressively perturbed glucose metabolism in a cross-sectional study.

Methods

19 iRBD patients, 38 PD patients and 19 HC subjects underwent ¹⁸F-FDG PET. The images were spatially n

SUBMITTER: Han X 

PROVIDER: S-EPMC7322340 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature