Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection.

ABSTRACT: HIV-associated sensory neuropathy is a common neurologic comorbidity of HIV infection and prevails in the post-antiretroviral therapy (ART) era. HIV infection drives pathologic changes in the dorsal root ganglia (DRG) through inflammation, altered metabolism, and neuronal dysfunction. Herein, we characterized specific neuronal populations in an SIV-infected macaque model with or without ART. DRG neuronal populations were identified by neurofilament H-chain 200, I-B₄ isolectin (IB4), or tropomyosin receptor kinase A expression and assessed for cell body diameter, population size, apoptotic markers, and regeneration signaling. IB4⁺ and tropomyosin receptor kinase A-positive neurons showed a reduced cell body size (atrophy) and decreased population size (cell death) in t

SUBMITTER: Robinson JA 

PROVIDER: S-EPMC7322364 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature