Gene testing for osteonecrosis of the femoral head in systemic lupus erythematosus using targeted next-generation sequencing: A pilot study.

ABSTRACT:

Background

Previous publications indicated that genetic predisposition might play important roles in the onset of osteonecrosis of the femoral head (ONFH) in systemic lupus erythematosus (SLE). Some gene loci such as complement C3d receptor 2 (CR2), nitric oxide synthase 3 (NOS3), collagen type II alpha 1 chain (COL2A1), protein tyrosine phosphatase non-receptor type 22 (PTPN22), and transient receptor potential cation channel subfamily V member 4 (TRPV4) were reported to be involved in this process.

Aim

To investigate whether the risk of ONFH in SLE is associated with single nucleotide variations (SNVs) in these five genes.

Methods

SNVs in the CR2, NOS3, COL2A1, PTPN22, and TRPV4 genes were examine

SUBMITTER: Sun HS 

PROVIDER: S-EPMC7322418 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature