Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study.

ABSTRACT:

Background

Alzheimer's disease and its complications are the leading cause of death in adults with Down syndrome. Studies have assessed Alzheimer's disease in individuals with Down syndrome, but the natural history of biomarker changes in Down syndrome has not been established. We characterised the order and timing of changes in biomarkers of Alzheimer's disease in a population of adults with Down syndrome.

Methods

We did a dual-centre cross-sectional study of adults with Down syndrome recruited through a population-based health plan in Barcelona (Spain) and through services for people with intellectual disabilities in Cambridge (UK). Cognitive impairment in participants with Down syndrome was classified with the Cambridge Cognitive Examination for Older Adults with Down Syn

SUBMITTER: Fortea J 

PROVIDER: S-EPMC7322523 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature