Development of a risk score for early saphenous vein graft failure: An individual patient data meta-analysis.

ABSTRACT:

Objectives

Early saphenous vein graft (SVG) occlusion is typically attributed to technical factors. We aimed at exploring clinical, anatomical, and operative factors associated with the risk of early SVG occlusion (within 12 months postsurgery).

Methods

Published literature in MEDLINE was searched for studies reporting the incidence of early SVG occlusion. Individual patient data (IPD) on early SVG occlusion were used from the SAFINOUS-CABG Consortium. A derivation (n = 1492 patients) and validation (n = 372 patients) cohort were used for model training (with 10-fold cross-validation) and external validation respectively.

Results

In aggregate data meta-analysis (48 studies, 41,530 SVGs) the pooled estimate for early SVG occlusion was 11%. The developed IPD model for e

SUBMITTER: Antonopoulos AS 

PROVIDER: S-EPMC7322547 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature