Poorly controlled diabetes mellitus alters placental structure, efficiency, and plasticity.

ABSTRACT:

Introduction

The hemochorial placenta provides a critical barrier at the maternal-fetal interface to modulate maternal immune tolerance and enable gas and nutrient exchange between mother and conceptus. Pregnancy outcomes are adversely affected by diabetes mellitus; however, the effects of poorly controlled diabetes on placental formation, and subsequently fetal development, are not fully understood.

Research design and methods

Streptozotocin was used to induce hyperglycemia in pregnant rats for the purpose of investigating the impact of poorly controlled diabetes on placental formation and fetal development. The experimental paradigm of hypoxia exposure in the pregnant rat was also used to assess properties of placental plasticity. Euglycemic and hyperglycemic rats were exp

SUBMITTER: Nteeba J 

PROVIDER: S-EPMC7322553 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature