Integration of genomics, metagenomics, and metabolomics to identify interplay between susceptibility alleles and microbiota in adenoma initiation.

ABSTRACT:

Background

Colorectal cancer (CRC) is a multifactorial disease resulting from both genetic predisposition and environmental factors including the gut microbiota (GM), but deciphering the influence of genetic variants, environmental variables, and interactions with the GM is exceedingly difficult. We previously observed significant differences in intestinal adenoma multiplicity between C57BL/6 J-Apc^Min (B6-Min/J) from The Jackson Laboratory (JAX), and original founder strain C57BL/6JD-Apc^Min (B6-Min/D) from the University of Wisconsin.

Methods

To resolve genetic and environmental interactions and determine their contributions we utilized two genetically inbred, independently isolated Apc^Min mouse colonies that have been separated for over 20 g

SUBMITTER: Moskowitz JE 

PROVIDER: S-EPMC7322931 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature