Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients.

ABSTRACT: Trauma-induced coagulopathy (TIC) is a complex, multifactorial failure of hemostasis that occurs in 25% of severely injured patients and results in a fourfold higher mortality. However, the role of platelets in this state remains poorly understood. We set out to identify molecular changes that may underpin platelet dysfunction after major injury and to determine how they relate to coagulopathy and outcome. We performed a range of hemostatic and platelet-specific studies in blood samples obtained from critically injured patients within 2 hours of injury and collected prospective data on patient characteristics and clinical outcomes. We observed that, although platelet counts were preserved above critical levels, circulating platelets sampled from trauma patients exhibited a profoundly reduc

SUBMITTER: Vulliamy P 

PROVIDER: S-EPMC7322946 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature