CD4+ T-cell killing of multiple myeloma cells is mediated by resident bone marrow macrophages.

ABSTRACT: CD4+ T cells may induce potent antitumor immune responses through interaction with antigen-presenting cells within the tumor microenvironment. Using a murine model of multiple myeloma, we demonstrated that adoptive transfer of idiotype-specific CD4+ T cells may elicit curative responses against established multifocal myeloma in bone marrow. This finding indicates that the myeloma bone marrow niche contains antigen-presenting cells that may be rendered tumoricidal. Given the complexity of the bone marrow microenvironment, the mechanistic basis of such immunotherapeutic responses is not known. Through a functional characterization of antitumor CD4+ T-cell responses within the bone marrow microenvironment, we found that killing of myeloma cells is orchestrated by a population of bone marrow-r

SUBMITTER: Haabeth OAW 

PROVIDER: S-EPMC7322971 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature