Genetic variability of human angiotensin-converting enzyme 2 (hACE2) among various ethnic populations.

ABSTRACT:

Background

There appears to be large regional variation for susceptibility, severity, and mortality for COVID-19 infections. Numerous potential factors could explain the wide variability in the number of infections and death among the countries. We examined genetic differences in the human angiotensin-converting enzyme 2 (hACE2) gene, as its receptor serves as a cellular entry for SARS-CoV-2. At present, there is a paucity of data regarding the differences for ACE2 polymorphisms and expression levels between ethnicities.

Methods

We compared the allele frequency of mutations between European and East Asians. Molecular dynamic simulation were performed to investigate the influences of significant mutant on protein structure. The binding free energies were calculated between S

SUBMITTER: Li Q 

PROVIDER: S-EPMC7323111 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature