The impact of pregnancy on the pharmacokinetics of antidepressants: a systematic critical review and meta-analysis.

ABSTRACT: Introduction: Pregnancy-related physiological changes exert a crucial impact on the pharmacokinetics of antidepressants; however, the current evidence presents inconsistencies. A clearer understanding of pregnancy-related effects on antidepressant disposition may facilitate the development of guidelines for appropriate dose adjustments during the course of pregnancy based on therapeutic drug monitoring.Areas covered: We systematically reviewed studies comparing antidepressant levels in the same individuals during pregnant and non-pregnant states. Using dose-adjusted plasma concentration measurements, we estimated alteration ratios between the 3rd trimester and baseline (before or after pregnancy). Additionally, we performed a meta-analysis for changes in dose-adjusted concent

SUBMITTER: Schoretsanitis G 

PROVIDER: S-EPMC7323120 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature