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C1 esterase inhibitor and the contact system in COVID-19.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life-threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus-2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen-specific mechanism that may help explain significant systemic abnormalities in patients with COVID-19.

SUBMITTER: Thomson TM

PROVIDER: S-EPMC7323335 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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C1 esterase inhibitor and the contact system in COVID-19.

Thomson Timothy M TM Toscano-Guerra Emily E Casis Ernesto E Paciucci Rosanna R Paciucci Rosanna R

British journal of haematology 20200728 4

Coronavirus disease 2019 (COVID-19) is frequently associated with severe systemic consequences, including vasculitis, a hyperinflammatory state and hypercoagulation. The mechanisms leading to these life-threatening abnormalities are multifactorial. Based on the analysis of publicly available interactomes, we propose that severe acute respiratory syndrome coronavirus-2 infection directly causes a deficiency in C1 esterase inhibitor, a pathogen-specific mechanism that may help explain significant ...[more]

PMID: 32531085

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Self-administration of intravenous C1 esterase inhibitor in hereditary angioedema.

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Gene therapy for C1 esterase inhibitor deficiency in a Murine Model of Hereditary angioedema.

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| S-EPMC6752709 | biostudies-literature

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