Generation of an in vitro model of the outer annulus fibrosus-cartilage interface.

ABSTRACT: Current treatments for degenerative disc disease do not restore full biological functionality of the intervertebral disc (IVD). As a result, regenerative medicine approaches are being developed to generate a biological replacement that when implanted will restore form and function of the degenerated IVD. Tissue-engineered models to date have focused on the generation of nucleus pulposus and annulus fibrosus IVD components. However, these tissues need to be integrated with a cartilage endplate in order for successful implantation to occur. The purpose of this study was to generate an in vitro annulus fibrosus-cartilage interface model which would enable us to better understand the biological and biomechanical implications of such interfaces. It was hypothesized that in vitro-formed outer an

SUBMITTER: Chong JE 

PROVIDER: S-EPMC7323466 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature