RIG-I and TLR4 responses and adverse outcomes in pediatric influenza-related critical illness.

ABSTRACT:

Background

Decreased TNF-α production in whole blood after ex vivo LPS stimulation indicates suppression of the Toll-like receptor (TLR)4 pathway. This is associated with increased mortality in pediatric influenza critical illness. Whether antiviral immune signaling pathways are also suppressed in these patients is unclear.

Objectives

We sought to evaluate suppression of the TLR4 and the antiviral retinoic acid-inducible gene-I (RIG-I) pathways with clinical outcomes in children with severe influenza infection.

Methods

In this 24-center, prospective, observational cohort study of children with confirmed influenza infection, blood was collected within 72 hours of intensive care unit admission. Ex vivo whole blood stimulations were performed with matched controls using

SUBMITTER: Novak T 

PROVIDER: S-EPMC7323584 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature