Ordinal dose-response modeling approach for the phthalate syndrome.

ABSTRACT:

Background

The phthalate syndrome (PS) is a collection of related male reproductive developmental effects, ranging in severity, that have been observed in rats after gestational exposure to developmentally-toxic phthalates. For statistical purposes, the PS is defined as a single endpoint and one dose-response analysis is conducted, rather than conducting multiple analyses on each individual endpoint.

Objective

To improve dose-response modeling approaches for the PS and other syndromes of effects by accounting for differing severity levels among the endpoints.

Methods

Ordinal dose-response modeling was performed on PS data from a published study of diisobutyl phthalate (DIBP) gestational exposure to male Sprague-Dawley rats. To incorporate PS endpoint severity, the end

SUBMITTER: Blessinger TD 

PROVIDER: S-EPMC7323710 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature