Ontology highlight
ABSTRACT:
SUBMITTER: Zou Y
PROVIDER: S-EPMC7323873 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Developmental cell 20200319 2
Understanding of NAD<sup>+</sup> metabolism provides many critical insights into health and diseases, yet highly sensitive and specific detection of NAD<sup>+</sup> metabolism in live cells and in vivo remains difficult. Here, we present ratiometric, highly responsive genetically encoded fluorescent indicators, FiNad, for monitoring NAD<sup>+</sup> dynamics in living cells and animals. FiNad sensors cover physiologically relevant NAD<sup>+</sup> concentrations and sensitively respond to increase ...[more]