Molecular determinants of drug response in TNBC cell lines.

ABSTRACT:

Purpose

There is a need for biomarkers of drug efficacy for targeted therapies in triple-negative breast cancer (TNBC). As a step toward this, we identify multi-omic molecular determinants of anti-TNBC efficacy in cell lines for a panel of oncology drugs.

Methods

Using 23 TNBC cell lines, drug sensitivity scores (DSS₃) were determined using a panel of investigational drugs and drugs approved for other indications. Molecular readouts were generated for each cell line using RNA sequencing, RNA targeted panels, DNA sequencing, and functional proteomics. DSS₃ values were correlated with molecular readouts using a FDR-corrected significance cutoff of p* < 0.05 and yielded molecular determinant panels that predict anti-TNBC efficacy.

Results

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SUBMITTER: Merrill NM 

PROVIDER: S-EPMC7323911 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature