IL-1R Regulates Disease Tolerance and Cachexia in Toxoplasma gondii Infection.

ABSTRACT: Toxoplasma gondii is an obligate intracellular parasite that establishes life-long infection in a wide range of hosts, including humans and rodents. To establish a chronic infection, pathogens often exploit the trade-off between resistance mechanisms, which promote inflammation and kill microbes, and tolerance mechanisms, which mitigate inflammatory stress. Signaling through the type I IL-1R has recently been shown to control disease tolerance pathways in endotoxemia and Salmonella infection. However, the role of the IL-1 axis in T. gondii infection is unclear. In this study we show that IL-1R^-/- mice can control T. gondii burden throughout infection. Compared with wild-type mice, IL-1R^-/- mice have more severe liver and adipose tissue path

SUBMITTER: Melchor SJ 

PROVIDER: S-EPMC7323938 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature