Effects of stress-induced inflammation on reward processing in healthy young women.

ABSTRACT:

Background

Anhedonia, or loss of interest or pleasure, is a feature of depression and transdiagnostic construct in psychopathology. Theory and compelling evidence from preclinical models implicates stress-induced inflammation as a psychobiological pathway to anhedonic behavior; however, this pathway has not been tested in human models. Further, although anhedonia may reflect dysregulation in multiple dimensions of reward, the extent to which stress-induced inflammation alters these dimensions is unclear. Thus, the current experimental study used a standardized laboratory stressor task to elicit an inflammatory response and evaluate effects of stress-induced inflammation on multiple behavioral indices of reward processing.

Methods

Healthy young women (age 18-25) completed beh

SUBMITTER: Boyle CC 

PROVIDER: S-EPMC7324155 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature