Ontology highlight
ABSTRACT:
SUBMITTER: Poropatich K
PROVIDER: S-EPMC7324178 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20200701 7
Plasmacytoid DCs (pDCs), the major producers of type I interferon, are principally recognized as key mediators of antiviral immunity. However, their role in tumor immunity is less clear. Depending on the context, pDCs can promote or suppress antitumor immune responses. In this study, we identified a naturally occurring pDC subset expressing high levels of OX40 (OX40+ pDC) enriched in the tumor microenvironment (TME) of head and neck squamous cell carcinoma. OX40+ pDCs were distinguished by a dis ...[more]