Cytoplasmic versus nuclear THR alpha expression determines survival of ovarian cancer patients.

ABSTRACT:

Purpose

Thyroid hormone receptors (THR) have manifold functions and are involved in the carcinogenesis of several tumor types. Within this study, we aimed to investigate the expression pattern (nuclear versus cytoplasmic) of the THR alpha and its impact on patients survival in ovarian cancer (OvCa).

Methods

The presence of the thyroid hormone receptors THRα, THRα1 and - 2 was investigated in 156 ovarian cancer samples using immunohistochemistry (IHC) using semi-quantitative immunoreactivity (IR) scores and correlated with clinical, pathological data, subtype of ovarian cancer, clinical data, staining of 20 already described OvCa marker proteins and overall survival (OS).

Results

Among all subtypes of OvCa, clear cell carcinomas showed the highest THRα expression. Furt

SUBMITTER: Ditsch N 

PROVIDER: S-EPMC7324415 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature