Kasumi leukemia cell lines: characterization of tumor genomes with ethnic origin and scales of genomic alterations.

ABSTRACT: Kasumi-1 has played an important role in an experimental model with t(8;21) translocation, which is a representative example of leukemia cell lines. However, previous studies using Kasumi-1 show discrepancies in the genome profile. The wide use of leukemia cell lines is limited to lines that are well-characterized. The use of additional cell lines extends research to various types of leukemia, and to further explore leukemia pathogenesis, which can be achieved by uncovering the fundamental features of each cell line with accurate data. In this study, ten Kasumi cell lines established in Japan, including five that were previously unknown, have been characterized by SNP microarray and targeted sequencing. SNP genotyping suggested that the genetic ancestry in four of the ten Kasumi cell lines

SUBMITTER: Kasai F 

PROVIDER: S-EPMC7324421 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature