Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.

ABSTRACT:

Background

Postoperative cognitive dysfunction (POCD) is one of the severe complications after surgery, inducing low life quality and high mortality, especially in elderly patients. However, the underlying molecular mechanism of POCD remains largely unknown, and the ideal biomarker for clinical diagnosis and prognosis is lacking. Circular RNAs (circRNAs), as a unique class of non-coding RNAs, were characterized by its stability and conservativeness, serving as novel biomarkers in various diseases. Nevertheless, the role of circRNAs in the occurrence of POCD remains elusive.

Methods

To investigate the differentially expressed circRNAs in the serum of POCD patients and its potential role in the development of POCD, we performed a circRNA microarray to screen the differentially

SUBMITTER: Gao R 

PROVIDER: S-EPMC7324535 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature