Associations of oxygenated hemoglobin with disease burden and prognosis in stable COPD: Results from COSYCONET.

ABSTRACT: We studied whether in patients with stable COPD blood gases (BG), especially oxygenated hemoglobin (OxyHem) as a novel biomarker confer information on disease burden and prognosis and how this adds to the information provided by the comorbidity pattern and systemic inflammation. Data from 2137 patients (GOLD grades 1-4) of the baseline dataset of the COSYCONET COPD cohort were used. The associations with dyspnea, exacerbation history, BODE-Index (cut-off ≤2) and all-cause mortality over 3 years of follow-up were determined by logistic and Cox regression analyses, with sex, age, BMI and pack years as covariates. Predictive values were evaluated by ROC curves. Capillary blood gases included SaO₂, PaO₂, PaCO₂, pH, BE and the concentration of OxyHem [haemoglobi

SUBMITTER: Trudzinski FC 

PROVIDER: S-EPMC7324620 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature