Inflammation-Associated Synaptic Alterations as Shared Threads in Depression and Multiple Sclerosis.

ABSTRACT: In the past years, several theories have been advanced to explain the pathogenesis of Major Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general population. Several theories have been proposed to define the MDD pathophysiology such as the classic "monoamine-theory" or the "glutamate hypothesis." All these theories have been recently integrated by evidence highlighting inflammation as a pivotal player in developing depressive symptoms. Proinflammatory cytokines have been indeed claimed to contribute to stress-induced mood disturbances and to major depression, indicating a widespread role of classical mediators of inflammation in emotional control. Moreover, during systemic inflammatory diseases, peripherally released cytokines circulate in the blood, reach

SUBMITTER: Bruno A 

PROVIDER: S-EPMC7324636 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature