Regulation of Neurogenesis by FGF Signaling and Neurogenin in the Invertebrate Chordate Ciona.

ABSTRACT: Neurogenesis is a complex sequence of cellular processes and behaviors driven by the coordinated expression of conserved effectors. The bipolar tail neurons (BTNs) of Ciona develop according to a highly dynamic, yet highly stereotyped developmental program and thus could serve as an accessible model system for neurogenesis, including underlying cell behaviors like neuronal delamination, migration, and polarized axon outgrowth. Here we investigate both the upstream events that shape BTN neurogenesis through spatiotemporal regulation of the conserved proneural factor Neurog, spatiotemporal, and the gene expression profile of differentiating BTNs downstream of Neurog activity. We show that, although early FGF signaling is required for Neurog expression and BTN specification,

SUBMITTER: Kim K 

PROVIDER: S-EPMC7324659 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature