Role of tryptophan-metabolizing microbiota in mice diarrhea caused by Folium sennae extracts.

ABSTRACT:

Background

Although reports have provided evidence that diarrhea caused by Folium sennae can result in intestinal microbiota diversity disorder, the intestinal bacterial characteristic and specific mechanism are still unknown. The objective of our study was to investigate the mechanism of diarrhea caused by Folium sennae, which was associated with intestinal bacterial characteristic reshaping and metabolic abnormality.

Results

For the intervention of Folium sennae extracts, Chao1 index and Shannon index were statistical decreased. The Beta diversity clusters of mice interfered by Folium sennae extracts were distinctly separated from control group. Combining PPI network analysis, cytochrome P450 enzymes metabolism was the main signaling pathway of diarrhea caused by Folium se

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7325056 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature